2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1908):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W009313
    2',3'-O-Isopropylideneuridine
    		99.86%
    2',3'-O-Isopropylideneuridine is a modified uridine. 2',3'-O-Isopropylideneuridine can be used in the research of viral diseases (such as cytomegalovirus and varicella-zoster virus).
    2',3'-O-Isopropylideneuridine
  • HY-W130204
    N-Acetyl-2′-deoxycytidine
    		99.59%
    N-Acetyl-2′-deoxycytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N-Acetyl-2′-deoxycytidine
  • HY-152334
    2’-Chloro-2’-deoxyadenosine
    		98.53%
    2’-Chloro-2’-deoxyadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Chloro-2’-deoxyadenosine
  • HY-148504
    5'-ODMT cEt G Phosphoramidite (Amidite)
    		99.05%
    5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt G Phosphoramidite Amidite shows excellent safety and antisense activity.
    5'-ODMT cEt G Phosphoramidite (Amidite)
  • HY-W115309
    DMT-2'-F-iBu-G
    DMT-2'-F-iBu-G (5'-DMT-2'-F-ibu-dG) is a modified oligonucleotide. 2'-deoxy-2'-fluoro-modified oligonucleotides shows high nuclease resistant and retained exceptional binding affinity to the RNA targets.
    DMT-2'-F-iBu-G
  • HY-W008388
    Bz-rA
    		99.51%
    Bz-rA (N6-Benzoyladenosine) is a nucleoside derivative with an N6 protecting group. Bz-rA is mainly used as a synthetic intermediate to participate in photocatalytic oxidative cyclization reactions and synthesize oligoribonucleotides. Bz-rA can be used to efficiently construct heterocyclic skeletons in photochemical conversions and protect the ribose moiety to regulate the cyclization pathway.
    Bz-rA
  • HY-45491
    Dmt-2'-f-dc(ac) amidite
    		99.53%
    Dmt-2'-f-dc(ac) amidite (2'-F-Ac-dC Phosphoramidite) is a phosphoramidite which can be used in the preparation of cyclic purine dinucleotides.
    Dmt-2'-f-dc(ac) amidite
  • HY-154508
    FdUMP triethylammonium
    		99.96%
    FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU). 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.
    FdUMP triethylammonium
  • HY-W025438
    5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine
    		98.03%
    5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine is a uridine analog. 5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine is a key precursor for the synthesis of oligodeoxynucleotides containing a cyclic structure.
    5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine
  • HY-103694
    Nebularine
    		98.44%
    Nebularine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Nebularine
  • HY-104014
    DMT-2'O-MOE-rG(ib) Phosphoramidite
    DMT-2'O-MOE-rG(ib) Phosphoramidite belongs to cyanoethyl-protected nucleoside phosphoramidites. DMT-2'O-MOE-rG(ib) Phosphoramidite is a derivative of nucleotide and guanosine. DMT-2'O-MOE-rG(ib) Phosphoramidite can be used for the stereochemical synthesis of phosphorothioate oligonucleotides.
    DMT-2'O-MOE-rG(ib) Phosphoramidite
  • HY-13770
    Troxacitabine
    		99.95%
    Troxacitabine is nucleoside analog with potent anticancer activity.
    Troxacitabine
  • HY-108060A
    Valopicitabine dihydrochloride
    		99.79%
    Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination.
    Valopicitabine dihydrochloride
  • HY-B1449S8
    Uridine-d2-1
    		98.47%
    Uridine-d2-1 is the deuterium labeled Uridine.
    Uridine-d<sub>2</sub>-1
  • HY-115741
    3BrB-PP1
    		99.0%
    3BrB-PP1 is an ATP-competitive analog. 3BrB-PP1 can specifically inhibit the activity of protein kinase with mutations in the ATP-binding pocket (mutation of Thr97 within Sty1’s ATP-binding pocket).
    3BrB-PP1
  • HY-113139S
    1-Methylinosine-d3
    		99.0%
    1-Methylinosine-d3 is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA.
    1-Methylinosine-d<sub>3</sub>
  • HY-W108399
    3’-O-t-Bulyldimethylsilylthymidine
    		99.04%
    3’-O-t-Bulyldimethylsilylthymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-O-t-Bulyldimethylsilylthymidine
  • HY-125818S3
    Cytidine-5'-triphosphate-13C9 dilithium
    		99.0%
    Cytidine-5'-triphosphate-13C9 (Cytidine triphosphate-13C9 dilithium; 5'-CTP-13C9) dilithium is 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
    Cytidine-5'-triphosphate-<sup>13</sup>C<sub>9</sub> dilithium
  • HY-W006395
    1-Methylcytosine
    		Chemical ≥98.0%
    1-Methylcytosine is a methylated form of the DNA base cytosine and used as a nucleobase of hachimoji DNA, in which it pairs with Isoguanine.
    1-Methylcytosine
  • HY-111639
    2’-O,4’-C-Methyleneuridine
    		99.57%
    2’-O,4’-C-Methyleneuridine (Compound 15a) is a bicyclic nucleoside.
    2’-O,4’-C-Methyleneuridine