2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1834):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W128112
    1-(a-D-ribofuranosyl)uracil
    1-(a-D-ribofuranosyl)uracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1-(a-D-ribofuranosyl)uracil
  • HY-151414
    3'-Deoxyinosine
    		99.84%
    3'-Deoxyinosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3'-Deoxyinosine
  • HY-W007791
    Chloropurine riboside
    		99.93%
    Chloropurine riboside (6-Chloropurine riboside) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Purine nucleoside analogs represent cytotoxic agents with established activity in hematological malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Chloropurine riboside
  • HY-138585
    DMT-dG(dmf) Phosphoramidite
    		99.71%
    DMT-dG(dmf) Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides
    DMT-dG(dmf) Phosphoramidite
  • HY-W009234
    6-Chloroguanineriboside
    		98.02%
    6-Chloroguanineriboside (6-Chloroguanosine) is a purine nucleoside analog. 6-Chloroguanineriboside has extremely low affinity for guanosine binding sites in rat brain (Ki: 253.1 μM).
    6-Chloroguanineriboside
  • HY-W091788
    (2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine
    		99.56%
    (2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine is the isomer of 7-Deaza-2'-deoxy-7-iodoadenosine (HY-W048490), and can be used as an experimental control. 7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine.
    (2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine
  • HY-W251781
    4-Thio-2’-deoxyuridine
    		≥98.0%
    4-Thio-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4-Thio-2’-deoxyuridine
  • HY-W013052
    8-Bromo-2'-deoxyadenosine
    		≥98.0%
    8-Bromo-2'-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Bromo-2'-deoxyadenosine
  • HY-W347492
    6-O-Methyldeoxyguanosine
    		99.34%
    O6-Methyldeoxy guanosine; DNA adduct is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    6-O-Methyldeoxyguanosine
  • HY-138615S2
    Deoxythymidine-5'-triphosphate-13C10 dilithium
    Deoxythymidine-5'-triphosphate-13C10 (dTTP-13C10) dilithium is 13C-labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.
    Deoxythymidine-5'-triphosphate-<sup>13</sup>C<sub>10</sub> dilithium
  • HY-B0228S5
    Adenosine-13C
    		≥99.0%
    Adenosine-13C is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology,
    Adenosine-<sup>13</sup>C
  • HY-138590
    7-TFA-ap-7-Deaza-dA
    		98.81%
    7-TFA-ap-7-Deaza-dA is a modified nucleoside. 7-TFA-ap-7-Deaza-dA can be used in the synthesis of deoxyribonucleic acid or nucleic acid. 7-TFA-ap-7-Deaza-dA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    7-TFA-ap-7-Deaza-dA
  • HY-W130204
    N-Acetyl-2′-deoxycytidine
    		99.59%
    N-Acetyl-2′-deoxycytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N-Acetyl-2′-deoxycytidine
  • HY-W010744
    DMT-dI
    		99.40%
    DMT-dI (5'-O-DMT-dI) is a deoxyribonucleoside containing a hypoxanthine base. DMT-dI can be used to prepare convertible nucleoside derivatives to prepare modified oligonucleotides complementary to target genes for gene editing. DMT-dI can be used to study various conditions, disorders or diseases modified by adenosine.
    DMT-dI
  • HY-152448
    2’-Azido-2’-deoxycytidine
    		98.78%
    2’-Azido-2’-deoxycytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2’-Azido-2’-deoxycytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. 2’-Azido-2’-deoxycytidine is an azidonucleoside,and it should be phosphorylated twice to become an inhibitor of the nucleotide reductase.
    2’-Azido-2’-deoxycytidine
  • HY-148503
    5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
    		98.55%
    5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment.
    5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
  • HY-90006R
    5-Fluorouracil (Standard)
    		Inhibitor
    5-Fluorouracil (Standard) is the analytical standard of 5-Fluorouracil. This product is intended for research and analytical applications. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer. 5-Fluorouracil also inhibits HIV.
    5-Fluorouracil (Standard)
  • HY-148504
    5'-ODMT cEt G Phosphoramidite (Amidite)
    		98.89%
    5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt G Phosphoramidite Amidite shows excellent safety and antisense activity.
    5'-ODMT cEt G Phosphoramidite (Amidite)
  • HY-152493
    3’-O-(2-Methoxyethyl)guanosine
    		98.90%
    3’-O-(2-Methoxyethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
    3’-O-(2-Methoxyethyl)guanosine
  • HY-45491
    Dmt-2'-f-dc(ac) amidite
    		99.7%
    Dmt-2'-f-dc(ac) amidite (2'-F-Ac-dC Phosphoramidite) is a phosphoramidite which can be used in the preparation of cyclic purine dinucleotides.
    Dmt-2'-f-dc(ac) amidite